Setting the foundations for 3D X-ray histology (XRH)

This is a custom-designed µCT scanner optimised for high throughput 3D X-ray Histology. This scanner was designed by the μ-VIS and the XRH team and built by Nikon X-Tek systems Ltd. It is the cornerstone of the second phase of development of 3D X-ray Histology, which is fully funded by Wellcome Trust (2019-2022; £1.14M; Wellcome Trust, Biomedical Resource and Technology Development Grant).

The XRH scanner can be used for non-destructive radiographical and tomographical inspection of biomedically relevant specimens, and is optimised for high-throughput imaging of unstained formalin-fixed and paraffin-embedded (FFPE) soft tissue specimens.

The equipment was commissioned in January, 2020 and is hosted at the Biomedical Imaging Unit at University Hospital Southampton.

Take a tour of the scanning room

See inside the scanner

 

    a scanner being of loaded from a lorry

    XRH scanner 1

    UoS X-ray Histology Scanner (delivery)
    the scanner just outside the room

    XRH scanner 2

    UoS X-ray Histology Scanner (delivery)
    The machine being installed and tested

    XRH scanner 3

    UoS X-ray Histology Scanner (commissioning)
    The team standing in front of the scanner after being installed

    XRH scanner 4

    UoS X-ray Histology Scanner (acceptance) - Prof. Mark Smith, UoS VC & the XRH team
    A scientist using the scanner

    MedX

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Summary

XRH scanner | UoS 3D X-ray Histology Scanner

‣ Nikon multi-target micro focus X-ray source
↪ 130 kVp / 130 W Mo rotating target (custom)  
10 μm spot up to 50 W
↪ 180 kVp / 20 W Mo transmission targets (custom) 
1.5 μm spot up to 5 W
↪ 225 kVp / 225 W multimetal reflection target
2.5 μm spot up to 7 W
‣ sample autoloader | up to 10 specimens per rack (custom) 
‣ optimised for high throughput 3D X-ray Histology
‣ 2.8 x 2.8 k 16-bit flat panel detector
‣ Standard cone-beam & helical scanning
‣ samples up to ~400 mm and up to 50 kg

Location

University Hospital Southampton (UHS)